Quinine is a suppressive and therapeutic agent, more toxic and less effective than chloroquine but is valuable in chloroquine-resistant strains of p.
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ph of food vacuole of plasmodium specie is acidic while chloroquine is a weak base, leading to change in ph of food vacuole.
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abbreviations ae, adverse event;al, artemether-lumefantrine;cq, chloroquine;dot, directly observed treatment;g6pd, glucose-6-phosphate dehydrogenase;hb, haemoglobin;hr, hazard ratio;iqr, interquartile range;pq, primaquine;pyo, person-year of observation.
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one placebo-controlled randomized trial tested hydroxychloroquine administered on days 21-365 after transplantation in 95 patients and did not show effects on agvhd or cgvhd or on survival.
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hydroxychloroquine is taken once to twice a day .
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