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patients in this study were titrated to a total daily fluvoxamine dose of approximately 100 mg day over the first two weeks of the trial, following which the dose was adjusted within a range of 50-200 mg day on a b.
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when duloxetine 60 mg was co-administered with fluvoxamine 100 mg, a potent cyp1a2 inhibitor, to male subjects n 14 duloxetine auc was increased approximately 6-fold, the c max was increased about 2.
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