The medical therapy of prostatic symptoms mtops trial was a double-blind, randomized, placebocontrolled, multicenter, 4- to 6-year study average 5 years in 3047 men with symptomatic bph, who were randomized to receive proscar 5 mg day n 768 , doxazosin 4 or 8 mg day n 756 , the combination of proscar 5 mg day and doxazosin 4 or 8 mg day n 786 , or placebo n 737 .
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in these predominantly normocholesterolemic patients doxazosin mesylate produced small reductions in total serum cholesterol 2 to 3 , ldl cholesterol 4 , and a similarly small increase in hdl total cholesterol ratio 4 .
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in healthy volunteers, the administration of a single 1 mg dose of doxazosin on day 1 of a four-day regimen of oral cimetidine 400 mg twice daily resulted in a 10 increase in mean auc of doxazosin, and a slight but not significant increase in mean c max and mean half-life of doxazosin.
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